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- Title
Erythropoietin protects newborn rat against sevoflurane-induced neurotoxicity.
- Authors
Pellegrini, Lionel; Bennis, Youssef; Velly, Lionel; Grandvuillemin, Isabelle; Pisano, Pascale; Bruder, Nicolas; Guillet, Benjamin
- Abstract
Recent data on newborn animals exposed to anesthetics have raised safety concerns regarding anesthesia practices in young children. Indeed, studies on rodents have demonstrated a widespread increase in brain apoptosis shortly after exposure to sevoflurane, followed by long-term neurologic impairment. In this context, we aimed to evaluate the protective effect of rh-EPO, a potent neuroprotective agent, in rat pups exposed to sevoflurane.
- Publication
Paediatric anaesthesia, 2014, Vol 24, Issue 7, p749
- ISSN
1460-9592
- Publication type
Journal Article
- DOI
10.1111/pan.12372