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- Title
Mesangial cells are responsible for orchestrating the renal podocytes injury in the context of malignant hypertension.
- Authors
Berman, Sylvia; Abu Hamad, Ramzia; Efrati, Shai
- Abstract
Two populations of renal cells fully possess functional contractile cell apparatus: mesangial cells and podocytes. Previous studies demonstrated that in the context of malignant hypertension overproduction of Angiotensin-II by the contracting mesangial cells aggravated hypercellularity and apoptosis of adjacent cell populations. The role of podocytes in pathogenesis of malignant hypertension is unclear. We investigated responsiveness of normal vs. hyperglycaemic podocytes to pressure in a model of malignant hypertension.
- Publication
Nephrology (Carlton, Vic.), 2013, Vol 18, Issue 4, p292
- ISSN
1440-1797
- Publication type
Journal Article
- DOI
10.1111/nep.12043