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Title

Anti‐Ri‐antibodies associated paraneoplastic myelopathy revealing a woman's breast cancer: A case report.

Authors

Zouari, Rania; Ben Hmid, Ahlem; Abdellatif, Jihen; Zamali, Imen; Saeid, Mohamed Zakaria; Sassi, Samia Ben; Ben Ahmed, Melika

Abstract

Paraneoplastic myelopathy (PM) is an enigmatic immune‐mediated disorder rarely associated with breast cancer (BC) and anti‐Ri antibodies. Sometimes diagnosis is difficult due to the heterogeneity of symptoms and the timing of their onset. Herein, we report the case of a woman presenting with cervical myelopathy causing spastic left hemiplegia and painful spasms. Diagnosis of PM was confirmed through the positivity of well‐characterized onconeural antibodies (anti‐Ri) and the discovery of BC after a clinical examination and multiple investigations. We highlight, through this case, the importance of onconeural antibodies in the diagnosis of paraneoplastic neurological syndromes and associated cancer.

Subjects

PARANEOPLASTIC syndromes; BREAST cancer; SPINAL cord diseases; SYMPTOMS; SPASMS

Publication

Neurology & Clinical Neuroscience, 2025, Vol 13, Issue 1, p76

ISSN

2049-4173

Publication type

Academic Journal

DOI

10.1111/ncn3.12850

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