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- Title
Vitamin D in chronic liver disease.
- Authors
Stokes, Caroline S; Volmer, Dietrich A; Grünhage, Frank; Lammert, Frank
- Abstract
Chronic liver disease (CLD) and several related extrahepatic manifestations such as hepatic osteodystrophy are associated with deficiency of vitamin D, which has therefore been suggested as therapeutic target. Vitamin D undergoes hepatic 25-hydroxylation, rendering the liver critical to the metabolic activation of this vitamin. Vitamin D deficiency is highly prevalent in CLD patients, and vitamin D levels are inversely related to the severity of CLD. Declining levels of carrier proteins such as albumin and vitamin D-binding protein might also be critical in CLD. Intervention studies report improvements of CLD following supplementation, and benefits to health outcomes in particular with respect to hepatitis C virus infection have recently been documented.
- Publication
Liver international : official journal of the International Association for the Study of the Liver, 2013, Vol 33, Issue 3, p338
- ISSN
1478-3231
- Publication type
Journal Article
- DOI
10.1111/liv.12106