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- Title
Anti-factor IXa/X bispecific antibody (ACE910): hemostatic potency against ongoing bleeds in a hemophilia A model and the possibility of routine supplementation.
- Authors
Muto, A; Yoshihashi, K; Takeda, M; Kitazawa, T; Soeda, T; Igawa, T; Sakamoto, Y; Haraya, K; Kawabe, Y; Shima, M; Yoshioka, A; Hattori, K
- Abstract
We previously reported that a humanized anti-factor IXa/X bispecific antibody, hBS23, mimics the function of FVIII even in the presence of FVIII inhibitors, and has preventive hemostatic activity against bleeding in an animal model of acquired hemophilia A. After further molecular engineering of hBS23, we recently identified an improved humanized bispecific antibody, ACE910, for clinical investigation.
- Publication
Journal of thrombosis and haemostasis : JTH, 2014, Vol 12, Issue 2, p206
- ISSN
1538-7836
- Publication type
Journal Article
- DOI
10.1111/jth.12474