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Title
Molecular requirements for safer generation of thrombolytics by bioengineering the tissue-type plasminogen activator A chain.
Authors
Parcq, J; Bertrand, T; Baron, A F; Hommet, Y; Anglès-Cano, E; Vivien, D
Abstract
Thrombolysis with tissue-type plasminogen activator (t-PA) is the only treatment approved for acute ischemic stroke. Although t-PA is an efficient clot lysis enzyme, it also causes damage to the neurovascular unit, including hemorrhagic transformations and neurotoxicity.
Publication
Journal of thrombosis and haemostasis : JTH, 2013, Vol 11, Issue 3, p539