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- Title
Endogenous protein C has a protective role during Gram-negative pneumosepsis (melioidosis).
- Authors
Kager, L M; Wiersinga, W J; Roelofs, J J; Meijers, J C M; Zeerleder, S S; Esmon, C T; van't Veer, C; van der Poll, T
- Abstract
Activated protein C (APC) exerts anticoagulant effects via inactivation of factors Va and VIIIa and cytoprotective effects via protease activated receptor (PAR)1. Inhibition of endogenous APC in endotoxemia and sepsis results in exacerbation of coagulation and inflammation, with consequent enhanced lethality.
- Publication
Journal of thrombosis and haemostasis : JTH, 2013, Vol 11, Issue 2, p282
- ISSN
1538-7836
- Publication type
Journal Article
- DOI
10.1111/jth.12094