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- Title
Effectiveness of intracavernous delivery of adenovirus encoding Smad7 gene on erectile function in a mouse model of cavernous nerve injury.
- Authors
Song, Kang Moon; Chung, Jae-Seung; Choi, Min Ji; Jin, Hai-Rong; Yin, Guo Nan; Kwon, Mi-Hye; Park, Jin-Mi; Kim, Woo Jean; Lee, Sang-Jin; Kim, Seong-Jin; Ryu, Ji-Kan; Suh, Jun-Kyu
- Abstract
Men with erectile dysfunction (ED) respond poorly to oral phosphodiesterase-5 inhibitors following radical prostatectomy. Recent studies have reported that up-regulation of transforming growth factor-β1 (TGF-β1) and activation of the Smad signaling pathway play important roles in cavernous fibrosis and in the deterioration of erectile function in a mouse model of cavernous nerve injury (CNI) and in patients with spinal cord injury. The mothers against decapentaplegic homolog 7 (Smad7) is known to inhibit the phosphorylation of Smad2 and Smad3.
- Publication
The journal of sexual medicine, 2014, Vol 11, Issue 1, p51
- ISSN
1743-6109
- Publication type
Journal Article
- DOI
10.1111/jsm.12329