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- Title
Acidic deoxycholic acid and chenodeoxycholic acid induce interleukin-8 production through p38 mitogen-activated protein kinase and protein kinase A in a squamous epithelial model.
- Authors
Shan, Jing; Oshima, Tadayuki; Fukui, Hirokazu; Watari, Jiro; Miwa, Hiroto
- Abstract
Immune-mediated mucosal inflammation characterized by the production of interleukin (IL)-8 is associated with the development of gastroesophageal reflux disease. The effects of bile acids, which are major components of reflux fluid, on the production of IL-8 and related mechanisms remain unclear. This study aimed to address these questions using an esophageal stratified squamous epithelial model.
- Publication
Journal of gastroenterology and hepatology, 2013, Vol 28, Issue 5, p823
- ISSN
1440-1746
- Publication type
Journal Article
- DOI
10.1111/jgh.12139