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- Title
Colchicine toxicity precipitated by interaction with sunitinib.
- Authors
Abodunde, Oladapo A; LevakaVeera, Raghava Reddy; Desai, Ravi; Nweke, Nneka; Berrou, Mohammed
- Abstract
Colchicine is an anti-inflammatory agent used primarily in treatment of gout and familial Mediterranean fever. Toxicity is uncommon, and depends on dose, hepatic or renal impairment, co-administration with P-glycoprotein or CYP3A4 inhibitors and route of administration. In patients taking p-glycoprotein inhibitors, maximum recommended dose is 0·3 mg per day. In renal or hepatic impairment, recommendation is to avoid concomitant administration of p-glycoprotein inhibitors and colchicine.
- Publication
Journal of clinical pharmacy and therapeutics, 2013, Vol 38, Issue 3, p243
- ISSN
1365-2710
- Publication type
Journal Article
- DOI
10.1111/jcpt.12047