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- Title
Effect of recombinant canine interleukin-6 and interleukin-8 on tissue factor procoagulant activity in canine peripheral blood mononuclear cells and purified canine monocytes.
- Authors
Ogasawara, Seigo; Daddona, Janelle L; Trimpert, Jakob; Stokol, Tracy
- Abstract
Inflammation is a major cause of disseminated intravascular coagulation (DIC) in dogs, but underlying mechanisms for its initiation are unknown. We hypothesized that pro-inflammatory cytokines, interleukin (IL)-6 and IL-8, induce tissue factor (TF) expression on canine monocyte surfaces, which may contribute to DIC initiation.
- Publication
Veterinary clinical pathology, 2012, Vol 41, Issue 3, p325
- ISSN
1939-165X
- Publication type
Journal Article
- DOI
10.1111/j.1939-165X.2012.00437.x