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- Title
Peroxisome proliferator-activated receptor agonist treatment of alcohol-induced hepatic insulin resistance.
- Authors
de la Monte, Suzanne M; Pang, Maoyin; Chaudhry, Rajeev; Duan, Kevin; Longato, Lisa; Carter, Jade; Ouh, Jiyun; Wands, Jack R
- Abstract
Chronic ethanol exposure impairs insulin signaling in the liver. Peroxisome-proliferator activated receptor (PPAR) agonists function as insulin sensitizers and are used to treat type 2 diabetes mellitus. We examined the therapeutic effectiveness of PPAR agonists in reducing alcoholic hepatitis and hepatic insulin resistance in a model of chronic ethanol feeding.
- Publication
Hepatology research : the official journal of the Japan Society of Hepatology, 2011, Vol 41, Issue 4, p386
- ISSN
1872-034X
- Publication type
Journal Article
- DOI
10.1111/j.1872-034X.2011.00775.x