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- Title
Stability of bovine spongiform encephalopathy prions: absence of prion protein degradation by bovine gut microbiota.
- Authors
Böhnlein, C; Groschup, M H; Maertlbauer, E; Pichner, R; Gareis, M
- Abstract
Bovine spongiform encephalopathy (BSE) is transmitted by the oral route. However, the impacts of anaerobic fermentation processes in cattle on the stability of BSE-associated prion protein (PrP(Sc)) are still unresolved. In this study, experiments were designed to assess the ability of complex ruminal and colonic contents of bovines to degrade BSE-derived PrP(Sc). No significant decrease in PrP(Sc) levels in BSE brain homogenates was detected by Western blotting after up to 66 h of co-incubation with intestinal fluids. These results indicate that BSE-associated PrP(Sc) survive gastrointestinal digestion processes in cattle and might be excreted via faeces.
- Publication
Zoonoses and public health, 2012, Vol 59, Issue 4, p251
- ISSN
1863-2378
- Publication type
Journal Article
- DOI
10.1111/j.1863-2378.2012.01455.x