We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Test-retest reliability during fear acquisition and fear extinction in humans.
- Authors
Zeidan, Mohamed A; Lebron-Milad, Kelimer; Thompson-Hollands, Johanna; Im, Jamie J Y; Dougherty, Darin D; Holt, Daphne J; Orr, Scott P; Milad, Mohammed R
- Abstract
Classical fear conditioning and extinction has been used to understand the neurobiology of fear learning and its inhibition. The recall of an extinction memory involves the ventromedial prefrontal cortex and the amygdala, and patients with posttraumatic stress disorder (PTSD) have been shown to exhibit deficits in this process. Furthermore, extinction forms the basis of exposure therapies commonly used to treat PTSD patients. It is possible that effective pharmacological and/or psychological treatment regimens could influence the activity of these regions, and thereby increase the ability to retain an extinction memory. However, to test this, a fear conditioning and extinction paradigm must demonstrate within-subject reproducibility over time. We, therefore, sought to test the within-subject reliability of a previously used 2-day, classical fear conditioning and extinction paradigm.
- Publication
CNS neuroscience & therapeutics, 2012, Vol 18, Issue 4, p313
- ISSN
1755-5949
- Publication type
Journal Article
- DOI
10.1111/j.1755-5949.2011.00238.x