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- Title
All roads to schizophrenia lead to dopamine supersensitivity and elevated dopamine D2(high) receptors.
- Authors
Seeman, Philip
- Abstract
The dopamine D2 receptor is the common target for antipsychotics, and the antipsychotic clinical doses correlate with their affinities for this receptor. Antipsychotics quickly enter the brain to occupy 60-80% of brain D2 receptors in patients (the agonist aripiprazole occupies up to 90%), with most clinical improvement occurring within a few days. The D2 receptor can exist in a state of high-affinity (D2(High) ) or in a state of low-affinity for dopamine (D2Low).
- Publication
CNS neuroscience & therapeutics, 2011, Vol 17, Issue 2, p118
- ISSN
1755-5949
- Publication type
Journal Article
- DOI
10.1111/j.1755-5949.2010.00162.x