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- Title
Radioresistant malignant myoepithelioma of the breast with high level of ataxia telangiectasia mutated protein.
- Authors
Fang, Z M; Tse, R V; Marjoniemi, V M; Kozlov, S; Lavin, M F; Chen, H; Kearsley, J H; Graham, P H; Clarke, R A
- Abstract
Malignant myoepithelioma of the breast (MMB) is a rare and often aggressive disease with poor prognosis. Little is known regarding its optimal treatment and progression. We describe the clinical history of a woman following excision of a benign adenomyoepithelioma which recurred years later as a radioresistant malignant myoepithelioma with high levels of ataxia telangiectasia mutated protein and mutant p53 (Cys135Phe). MMB requires close follow-up and aggressive treatment. If adjuvant radiotherapy is adopted to improve local control, minimal postoperative delay and higher doses than for standard post-mastectomy radiation are recommended.
- Publication
Journal of medical imaging and radiation oncology, 2009, Vol 53, Issue 2, p234
- ISSN
1754-9485
- Publication type
Journal Article
- DOI
10.1111/j.1754-9485.2009.02053.x