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- Title
Vitamin D: criteria for safety and efficacy.
- Authors
Heaney, Robert P
- Abstract
The functional status indicator for vitamin D, for both safety and efficacy, is serum 25-hydroxyvitamin D concentration. Efficacy for several health endpoints requires levels of 80 nmol/L or higher. Toxicity occurs at levels of 500 nmol/L or higher. The input needed for efficacy, in addition to typical food and cutaneous inputs, will usually be 1000-2000 IU/day of supplemental cholecalciferol. Toxicity is associated only with excessive supplemental intake (usually well above 20,000 IU/day).
- Publication
Nutrition reviews, 2008, Vol 66, Issue 10 Suppl 2, pS178
- ISSN
1753-4887
- Publication type
Journal Article
- DOI
10.1111/j.1753-4887.2008.00102.x