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Title
Proton pump-inhibiting drugs, calcium homeostasis, and bone health.
Authors
Wright, Matthew J; Proctor, Deborah D; Insogna, Karl L; Kerstetter, Jane E
Abstract
Proton pump inhibitors (PPIs) are commonly used drugs, several of which are available without a prescription. Two recent studies have demonstrated increased hip fracture rates associated with PPI use. Theoretically, PPIs could impair intestinal calcium absorption resulting in increased rates of bone loss and a greater risk of fragility fracture.