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- Title
Insulin regulation of phosphoenolpyruvate carboxykinase-c gene transcription: the role of sterol regulatory element-binding protein 1c.
- Authors
Chakravarty, Kaushik; Hanson, Richard W
- Abstract
The effect of insulin on the regulation of phosphoenolpyruvate carboxykinase C (PEPCK-C) gene transcription, while pivotal for control of carbohydrate metabolism, constitutes only a small part of its overall action in cellular processes. Transcription of the PEPCK-C gene is the target for a number of pathways involved in the signal transduction initiated by insulin, and these processes involve an array of transcription factors and co-regulatory proteins that either alone or in concert bind to a subset of sites in the gene promoter to regulate its expression. This review will focus on a specific transcription factor, sterol regulatory element-binding protein 1c (SREBP-1c), and its role in the control of PEPCK-C gene transcription.
- Publication
Nutrition reviews, 2007, Vol 65, Issue 6 Pt 2, pS47
- ISSN
0029-6643
- Publication type
Journal Article
- DOI
10.1111/j.1753-4887.2007.tb00328.x