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- Title
Mutagenicity and safety evaluation of the water extract of Camellia oleifera Abel.
- Authors
Zhang, Ying; Chen, Qiuping; Luo, Xiaowei; Dai, Tiantian; Lu, Baiyi; Shen, Jianfu
- Abstract
The purpose of this study was to evaluate the mutagenicity and safety of water extract of the fruit hull of Camellia oleifera Abel (WECO), which was prepared using hot-reflux method. The oral maximum tolerated dose (MTD) of WECO was above 20 g/kg body weight both in rats and in mice, which can be regarded as virtually nontoxic. No mutagenicity was found in Ames test, mouse bone marrow cell micronucleus test and mouse sperm abnormality test. In the subacute study, the SD rats were administered orally at 0.5, 1, or 2 g/kg/BW for 30 d. There were no treatment-related toxic effects from WECO. No significant differences were found in parameters of body weight, hematology value, clinical chemistry value, and organ/body weight ratio. The level of no observed adverse effect level (NOAEL) for WECO was 2 g/kg/BW for subacute toxicity study.
- Publication
Journal of food science, 2011, Vol 76, Issue 3, pT84
- ISSN
1750-3841
- Publication type
Journal Article
- DOI
10.1111/j.1750-3841.2011.02101.x