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- Title
The IL-17 pathway as a major therapeutic target in autoimmune diseases.
- Authors
Hu, Yan; Shen, Fang; Crellin, Natasha K; Ouyang, Wenjun
- Abstract
Th17 cells are a subset of T helper cells that have been recently found to play important functions in host defense and the pathogenesis of various human autoimmune and inflammatory diseases. Th17 cells produce IL-17A, IL-17F, IL-22, and IL-21, of which IL-17A and IL-17F mediate many of the downstream pathologic functions of these cells. IL-17A and IL-17F signal through IL-17RA and IL-17RC heterodimeric receptors that are mainly expressed on tissue epithelial cells and fibroblasts. While IL-17A and IL-17F are important for host defense against many extracellular pathogens, they can also cause excessive tissue damage and exacerbate proinflammatory responses during autoimmunity. The IL-17 pathway, therefore, is a primary therapeutic target downstream of Th17 cells.
- Publication
Annals of the New York Academy of Sciences, 2011, Vol 1217, p60
- ISSN
1749-6632
- Publication type
Journal Article
- DOI
10.1111/j.1749-6632.2010.05825.x