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- Title
Intracellular life of Coxiella burnetii in macrophages.
- Authors
Ghigo, Eric; Pretat, Lionel; Desnues, Benoît; Capo, Christian; Raoult, Didier; Mege, Jean-Louis
- Abstract
Coxiella burnetii, the agent of Q fever, is an obligate intracellular bacterium that is considered a potential biological weapon of category B. C. burnetii survives within myeloid cells by subverting receptor-mediated phagocytosis and preventing phagosome maturation. The intracellular fate of C. burnetii also depends on the functional state of myeloid cells. This review describes the mechanisms used by C. burnetii to circumvent uptake and trafficking events, and the role of cytokines on C. burnetii survival in myeloid cells.
- Publication
Annals of the New York Academy of Sciences, 2009, Vol 1166, p55
- ISSN
1749-6632
- Publication type
Journal Article
- DOI
10.1111/j.1749-6632.2009.04515.x