We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
T1r3 and alpha-gustducin in gut regulate secretion of glucagon-like peptide-1.
- Authors
Kokrashvili, Zaza; Mosinger, Bedrich; Margolskee, Robert F
- Abstract
Glucagon-like peptide-1 (GLP-1) is an incretin hormone that underlies the augmented insulin release from the pancreas in response to glucose in the gut lumen more than to intravenous injected glucose (the "incretin effect"). GLP-1, found in enteroendocrine L cells of the gut, regulates appetite and gut motility and is released from L cells in response to glucose. GLP-1-expressing duodenal L cells also express T1r taste receptors, alpha-gustducin, and many other taste transduction elements. Knockout mice lacking alpha-gustducin or T1r3 have deficiencies in secretion of GLP-1 and in the regulation of plasma levels of insulin and glucose. Gut-expressed taste-signaling elements underlie multiple chemosensory functions of the gut including the incretin effect. Modulating hormone secretion from gut "taste cells" may provide novel treatments for obesity, diabetes, and malabsorption.
- Publication
Annals of the New York Academy of Sciences, 2009, Vol 1170, p91
- ISSN
1749-6632
- Publication type
Journal Article
- DOI
10.1111/j.1749-6632.2009.04485.x