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- Title
Skeletal muscle mass recovery from atrophy in IL-6 knockout mice.
- Authors
Washington, T A; White, J P; Davis, J M; Wilson, L B; Lowe, L L; Sato, S; Carson, J A
- Abstract
Skeletal muscle interleukin-6 (IL-6) expression is induced by continuous contraction, overload-induced hypertrophy and during muscle regeneration. The loss of IL-6 can alter skeletal muscle's growth and extracellular matrix remodelling response to overload-induced hypertrophy. Insulin-like growth factor-1 (IGF-1) gene expression and related signalling through Akt/mTOR is a critical regulator of muscle mass. The significance of IL-6 expression during the recovery from muscle atrophy is unclear. This study's purpose was to determine the effect of IL-6 loss on mouse gastrocnemius (GAS) muscle mass during recovery from hindlimb suspension (HS)-induced atrophy.
- Publication
Acta physiologica (Oxford, England), 2011, Vol 202, Issue 4, p657
- ISSN
1748-1716
- Publication type
Journal Article
- DOI
10.1111/j.1748-1716.2011.02281.x