We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effect of dapoxetine on ejaculatory performance and related brain neuronal activity in rapid ejaculator rats.
- Authors
Clément, Pierre; Laurin, Miguel; Compagnie, Sandrine; Facchinetti, Patricia; Bernabé, Jacques; Alexandre, Laurent; Giuliano, François
- Abstract
A brain network specifically activated when ejaculation occurs has been described in rats. Increasing serotonin (5-hydroxytryptamine [5-HT]) tone impairs ejaculation and chronic 5-HT selective serotonin reuptake inhibitors (SSRIs) are known to inhibit ejaculation. However, efficacy of acute treatment with SSRI varies from one compound to another. The SSRI dapoxetine has been reported to delay ejaculation when given on demand to men with premature ejaculation (PE), although the mechanism of action is unclear. Effects of acute SSRIs on activity of the brain ejaculation circuit in relation with ejaculation have never been examined.
- Publication
The journal of sexual medicine, 2012, Vol 9, Issue 10, p2562
- ISSN
1743-6109
- Publication type
Journal Article
- DOI
10.1111/j.1743-6109.2012.02884.x