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- Title
WNT2 locus is involved in genetic susceptibility of Peyronie's disease.
- Authors
Dolmans, Guido H; Werker, Paul M; de Jong, Igle J; Nijman, Rien J; Wijmenga, Cisca; Ophoff, Roel A; LifeLines Cohort Study
- Abstract
Peyronie's disease (PD) is a fibromatosis of the penis, with a pathology very similar to what is seen in the hand (palmar fascia) in Dupuytren's disease (DD). Recently, we performed a genome-wide association study and identified nine genetic loci containing common variants associated with DD. Seven of these loci mapped within or near genes of the canonical WNT pathway and each locus yielded relatively large odds ratios (ORs) for DD disease status.
- Publication
The journal of sexual medicine, 2012, Vol 9, Issue 5, p1430
- ISSN
1743-6109
- Publication type
Journal Article
- DOI
10.1111/j.1743-6109.2012.02704.x