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- Title
Clomiphene citrate effects on testosterone/estrogen ratio in male hypogonadism.
- Authors
Shabsigh, Ahmad; Kang, Young; Shabsign, Ridwan; Gonzalez, Mark; Liberson, Gary; Fisch, Harry; Goluboff, Erik
- Abstract
Symptomatic late-onset hypogonadism is associated not only with a decline in serum testosterone, but also with a rise in serum estradiol. These endocrine changes negatively affect libido, sexual function, mood, behavior, lean body mass, and bone density. Currently, the most common treatment is exogenous testosterone therapy. This treatment can be associated with skin irritation, gynecomastia, nipple tenderness, testicular atrophy, and decline in sperm counts. In this study we investigated the efficacy of clomiphene citrate in the treatment of hypogonadism with the objectives of raising endogenous serum testosterone (T) and improving the testosterone/estrogen (T/E) ratio.
- Publication
The journal of sexual medicine, 2005, Vol 2, Issue 5, p716
- ISSN
1743-6095
- Publication type
Journal Article
- DOI
10.1111/j.1743-6109.2005.00075.x