Title

A structural overview of the PDI family of proteins.

Authors

Kozlov, Guennadi; Määttänen, Pekka; Thomas, David Y.; Gehring, Kalle

Abstract

Protein disulfide isomerases (PDIs) are enzymes that mediate oxidative protein folding in the endoplasmic reticulum. Understanding of PDIs has historically been hampered by lack of structural information. Over the last several years, partial and full-length PDI structures have been solved at an increasing rate. Analysis of the structures reveals common features shared by several of the best known PDI family members, and also unique features related to substrate and partner binding sites. These exciting breakthroughs provide a deeper understanding of the mechanisms of oxidative protein folding in cells.

Subjects

PROTEIN disulfide isomerase; PROTEIN folding; PROTEIN conformation; ENDOPLASMIC reticulum; IMMUNOGLOBULIN idiotypes

Publication

FEBS Journal, 2010, Vol 277, Issue 19, p3924

ISSN

1742-464X

Publication type

Academic Journal

DOI

10.1111/j.1742-4658.2010.07793.x