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- Title
The undecided serpin. The ins and outs of plasminogen activator inhibitor type 2.
- Authors
Medcalf, Robert L; Stasinopoulos, Stan J
- Abstract
Plasminogen activator inhibitor type-2 (PAI-2) is a nonconventional serine protease inhibitor (serpin) with unique and tantalizing properties that is generally considered to be an authentic and physiological inhibitor of urokinase. However, the fact that only a small percentage of PAI-2 is secreted has been a long-standing argument for alternative roles for this serpin. Indeed, PAI-2 has been shown to have a number of intracellular roles: it can alter gene expression, influence the rate of cell proliferation and differentiation, and inhibit apoptosis in a manner independent of urokinase inhibition. Despite these recent advances in defining the intracellular function of PAI-2, it still remains one of the most mysterious and enigmatic members of the serpin superfamily.
- Publication
The FEBS journal, 2005, Vol 272, Issue 19, p4858
- ISSN
1742-464X
- Publication type
Journal Article
- DOI
10.1111/j.1742-4658.2005.04879.x