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- Title
Stability and antimicrobial effectiveness of treprostinil sodium in Sterile Diluent for Flolan.
- Authors
Zaccardelli, D; Phares, K; Jeffs, R; Doran, A; Wade, M
- Abstract
Long-term intravenous infusion of epoprostenol and treprostinil for treatment of pulmonary arterial hypertension (PAH) via a central venous catheter is associated with the risk of bloodstream infection (BSI). While several potential explanations exist for possible differences in BSI incidence among intravenous prostanoids, one hypothesis suggests that the alkaline pH of epoprostenol in Sterile Diluent for Flolan (SDF) has greater antimicrobial activity compared with the neutral pH of other common diluents such as sterile saline or water, which have been used for treprostinil.
- Publication
International journal of clinical practice, 2010, Vol 64, Issue 7, p885
- ISSN
1742-1241
- Publication type
Journal Article
- DOI
10.1111/j.1742-1241.2009.02307.x