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- Title
Local treatment of empyema in children: a systematic review of randomized controlled trials.
- Authors
Krenke, Katarzyna; Peradzyńska, Joanna; Lange, Joanna; Ruszczyński, Marek; Kulus, Marek; Szajewska, Hania
- Abstract
The aim of the study is to systematically evaluate data from randomized controlled trials (RCTs) on the efficacy of using intrapleural fibrinolytic agents in the treatment of complicated parapneumonic effusions or empyema in children. The Cochrane Library, MEDLINE and EMBASE databases were searched in July 2009. Four RCTs, involving 194 children, were included. In two RCTs, intrapleural fibrinolytic treatment was compared with normal saline. One of these RCTs showed a significantly reduced hospital stay in those treated with urokinase compared with those treated with normal saline. Otherwise, no fibrinolytic agent had an effect on any other outcome. Two RCTs that compared fibrinolytic treatment with video-assisted thoracoscopic surgery (VATS) revealed no benefit of VATS.
- Publication
Acta paediatrica (Oslo, Norway : 1992), 2010, Vol 99, Issue 10, p1449
- ISSN
1651-2227
- Publication type
Journal Article
- DOI
10.1111/j.1651-2227.2010.01863.x