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Title
Tight junctions, leaky intestines, and pediatric diseases.
Authors
Liu, Z; Li, N; Neu, J
Abstract
Tight junctions (TJs) represent the major barrier within the paracellular pathway between intestinal epithelial cells. Disruption of TJs leads to intestinal hyperpermeability (the so-called "leaky gut") and is implicated in the pathogenesis of several acute and chronic pediatric disease entities that are likely to have their origin during infancy.