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- Title
Leptin deficiency modulates allograft survival by favoring a Th2 and a regulatory immune profile. [corrected].
- Authors
Moraes-Vieira, P M M; Bassi, E J; Larocca, R A; Castoldi, A; Burghos, M; Lepique, A P; Quintana, F J; Araujo, R C; Basso, A S; Strom, T B; Câmara, N O S
- Abstract
Leptin, an adipose-secreted hormone, links metabolism and immunity. Our aim was to determine whether leptin affects the alloimmune response. We used an allogeneic skin transplant model as a means to analyze the allograft immune response in Lep(ob/ob) and wild-type mice. Leptin deficiency results in an increased frequency of Treg and Th2 cells and a prolonged graft survival. These effects of leptin deficiency indicate the importance of leptin and obesity in modulating the allograft immune responses. Our data suggest a possible explanation for the increased susceptibility of hyperleptinemic obese patients to acute and chronic graft rejection.
- Publication
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2013, Vol 13, Issue 1, p36
- ISSN
1600-6143
- Publication type
Journal Article
- DOI
10.1111/j.1600-6143.2012.04283.x