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- Title
Regulatory T-cell counter-regulation by innate immunity is a barrier to transplantation tolerance.
- Authors
Kim, J I; Lee, M K, 4th; Moore, D J; Sonawane, S B; Duff, P E; O'Connor, M R; Yeh, H; Lian, M M; Deng, S; Caton, A J; Markmann, J F
- Abstract
Innate immune signals foster adaptive immunity through activation of antigen-presenting cells. Recent in vitro evidence suggests that innate signaling may also contribute to immunity by countering the effects of regulatory T cells (T-regs), counter-regulation. We present in vivo evidence using a transgenic skin allograft model that the function of T-regs is lost in the setting of acute skin transplantation but remains intact when grafts were transplanted 1 month prior to allow surgery-induced inflammation to abate. Our findings identify T-reg counter-regulation as a naturally occurring process that accompanies transplantation and an important barrier to T-reg-mediated tolerance. Our finding further highlights the central role of regulatory cell deactivation in the initiation of the immune response.
- Publication
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2009, Vol 9, Issue 12, p2736
- ISSN
1600-6143
- Publication type
Journal Article
- DOI
10.1111/j.1600-6143.2009.02847.x