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- Title
Lipopolysaccharide appears to activate human endometrial endothelial cells through TLR-4-dependent and TLR-4-independent mechanisms.
- Authors
Krikun, Graciela; Trezza, Jordan; Shaw, Jeff; Rahman, Mizan; Guller, Seth; Abrahams, Vikki M; Lockwood, Charles J
- Abstract
Uterine innate immunity remains poorly characterized, and while endometrial endothelial cells are known to express Toll-like receptors (TLRs), little is known about their function in these cells. The present study evaluated the effect of Gram-negative bacterial lipopolysaccharide (LPS) on human endometrial endothelial cell (HEECs) cytokine secretion and tissue factor expression, and the role of TLR-4 in these responses.
- Publication
American journal of reproductive immunology (New York, N.Y. : 1989), 2012, Vol 68, Issue 3, p233
- ISSN
1600-0897
- Publication type
Journal Article
- DOI
10.1111/j.1600-0897.2012.01164.x