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- Title
Enhanced stimulation of anti-ovarian cancer CD8(+) T cells by dendritic cells loaded with nanoparticle encapsulated tumor antigen.
- Authors
Hanlon, Douglas J; Aldo, Paulomi B; Devine, Lesley; Alvero, Ayesha B; Engberg, Anna K; Edelson, Richard; Mor, Gil
- Abstract
Dendritic cell (DC)-based cancer therapies are favored approaches to stimulate anti-tumor T-cell responses. Unfortunately, tolerance to tumor antigens is difficult to overcome. Biodegradable poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NP) are effective reagents in the delivery of drugs and tumor-associated antigens (TAA). In this study, we assessed the capacity of a PLGA NP-based delivery system to augment CD8 T-cell responses to ovarian cancer TAA.
- Publication
American journal of reproductive immunology (New York, N.Y. : 1989), 2011, Vol 65, Issue 6, p597
- ISSN
1600-0897
- Publication type
Journal Article
- DOI
10.1111/j.1600-0897.2010.00968.x