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- Title
Uric acid induces trophoblast IL-1β production via the inflammasome: implications for the pathogenesis of preeclampsia.
- Authors
Mulla, Melissa J; Myrtolli, Kledia; Potter, Julie; Boeras, Crina; Kavathas, Paula B; Sfakianaki, Anna K; Tadesse, Serkelem; Norwitz, Errol R; Guller, Seth; Abrahams, Vikki M
- Abstract
Preeclampsia is associated with hyperuricemia, which correlates with the disease severity. Levels of circulating uric acid increase before the clinical manifestations, suggesting that they may be causally related. Uric acid, or monosodium urate (MSU), activates the Nod-like receptor, Nalp3, leading to inflammasome activation and IL-1β processing. Because preeclampsia is associated with placental immune⁄ inflammatory dysregulation, we sought to determine in the trophoblast, the presence of the Nalp3 inflammasome, and the effect of MSU on its activation.
- Publication
American journal of reproductive immunology (New York, N.Y. : 1989), 2011, Vol 65, Issue 6, p542
- ISSN
1600-0897
- Publication type
Journal Article
- DOI
10.1111/j.1600-0897.2010.00960.x