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- Title
Regulation of inflammation by the NF-κB pathway in ovarian cancer stem cells.
- Authors
Leizer, Aliza L; Alvero, Ayesha B; Fu, Han Hsuan; Holmberg, Jennie C; Cheng, Yung-Chi; Silasi, Dan-Arin; Rutherford, Thomas; Mor, Gil
- Abstract
The NFκB pathway is a major source of pro-inflammatory cytokines, which may contribute to cancer chemoresistance. We showed that constitutive NFκB activity is characteristic of the ovarian cancer stem cells (OCSCs). The aim of this study is to determine whether the inhibition of NFκB by Eriocalyxin B (EriB) in the OCSCs may induce cell death in otherwise chemoresistant cells.
- Publication
American journal of reproductive immunology (New York, N.Y. : 1989), 2011, Vol 65, Issue 4, p438
- ISSN
1600-0897
- Publication type
Journal Article
- DOI
10.1111/j.1600-0897.2010.00914.x