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- Title
Women with Multiple Implantation Failures and Recurrent Pregnancy Losses have Increased Peripheral Blood T Cell Activation.
- Authors
Kwang Moon Yang; Ntrivalas, Evangelos; Hye Jin Cho; Na Young Kim; Beaman, Kenneth; Gilman-Sachs, Alice; Kwak-Kim, Joanne
- Abstract
Citation Yang KM, Ntrivalas E, Cho HJ, Kim NY, Beaman K, Gilman-Sachs A, Kwak-Kim J. Women with multiple implantation failures and recurrent pregnancy losses have increased peripheral blood T cell activation. Am J Reprod Immunol 2010 Problem We aim to determine whether peripheral blood T cell activation is associated with repeated implantation failures or recurrent pregnancy losses (RPLs). Method of study Women with a history of repeated implantation failure ( n = 18) or RPLs ( n = 17) comprise the study group. Normal fertile women ( n = 11) are included as controls. Proportion of activated peripheral blood T cells (CD69+, CD154+) and Th1/Th2 cell ratios are measured by flow cytometric analysis. Results Proportions (%) of CD4+/154+ of CD4+ and CD8+/154+ of CD8+ cells were significantly higher in study group than those of controls. Proportions (%) of CD3+/69+ of CD3+ cells and CD8+/69+ of CD8+ cells were significantly increased in study group compared to controls. Proportion (%) of CD4+/69+ cells significantly correlated with % CD4+/154+ cells ( P = 0.003). Activated cytotoxic T cells (CD8+/154+, CD8+/69+) inversely correlated with INF-γ/IL-10 producing CD3+/4+ T cell ratios. Proportion of activated CD3+/8+/69 and CD3+/8+/154+ cells was inversely correlated with IFN-γ/IL-10 expressing CD3+/4+ T cell ratios. Conclusion Women with MIFs or RPLs have increased T cell activation in peripheral blood lymphocytes, and T cell suppressor activation seems to be associated with decreased Th1 immunity. Further studies on T cell activation may elucidate molecular mechanisms controlling Th1 effectors.
- Publication
American Journal of Reproductive Immunology, 2010, Vol 63, Issue 5, p370
- ISSN
1046-7408
- Publication type
Academic Journal
- DOI
10.1111/j.1600-0897.2010.00811.x