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- Title
Antiphospholipid antibodies limit trophoblast migration by reducing IL-6 production and STAT3 activity.
- Authors
Mulla, Melissa J; Myrtolli, Kledia; Brosens, Jan J; Chamley, Larry W; Kwak-Kim, Joanne Y; Paidas, Michael J; Abrahams, Vikki M
- Abstract
Women with antiphospholipid antibodies (aPL) are at risk of recurrent miscarriage and pre-eclampsia. aPL target the placenta by binding to beta(2)-glycoprotein I (beta(2) GPI) expressed by the trophoblast. The objective of this study was to evaluate if and how aPL affect first trimester trophoblast migration.
- Publication
American journal of reproductive immunology (New York, N.Y. : 1989), 2010, Vol 63, Issue 5, p339
- ISSN
1600-0897
- Publication type
Journal Article
- DOI
10.1111/j.1600-0897.2009.00805.x