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- Title
Antiphospholipid antibodies induce a pro-inflammatory response in first trimester trophoblast via the TLR4/MyD88 pathway.
- Authors
Mulla, Melissa J; Brosens, Jan J; Chamley, Larry W; Giles, Ian; Pericleous, Charis; Rahman, Anisur; Joyce, Shawna K; Panda, Britta; Paidas, Michael J; Abrahams, Vikki M
- Abstract
Women with antiphospholipid antibodies (aPL) are at risk for recurrent miscarriage, pre-eclampsia, and pre-term labor. aPL target the placenta directly by binding to beta(2)-glycoprotein I (beta(2)GPI) expressed on the surface of trophoblast cells. The objective of this study was to determine the effects of aPL on trophoblast function and the mechanisms involved.
- Publication
American journal of reproductive immunology (New York, N.Y. : 1989), 2009, Vol 62, Issue 2, p96
- ISSN
1600-0897
- Publication type
Journal Article
- DOI
10.1111/j.1600-0897.2009.00717.x