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- Title
Co-ordination of incoming and outgoing traffic in antigen-presenting cells by pattern recognition receptors and T cells.
- Authors
Nair, Priyanka; Amsen, Derk; Blander, J Magarian
- Abstract
Dendritic cells are innate sentinels of the immune system and potent activators of naÏve T cells. Mechanisms must exist to enable these cells to achieve maximal activation of T cells specific for microbial antigens, while avoiding activation of T cells specific for self-antigens. Here we discuss how a combination of signals from pattern recognition receptors and T cells co-ordinates subcellular trafficking of antigen with both major histocompatibility complex class I and class II molecules and T-cell costimulatory molecules, resulting in the preferential presentation of microbial peptides within a stimulatory context.
- Publication
Traffic (Copenhagen, Denmark), 2011, Vol 12, Issue 12, p1669
- ISSN
1600-0854
- Publication type
Journal Article
- DOI
10.1111/j.1600-0854.2011.01251.x