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- Title
Histopathologic changes in dental and oral soft tissues in 2-butoxyethanol-induced hemolysis and thrombosis in rats*.
- Authors
Redlich, M; Maly, A; Aframian, D; Shabat, S; Ezov, N; Levin-Harrus, T; Nyska, M; Nyska, A
- Abstract
2-Butoxyethanol (2-BE; ethylene glycol monobutyl ether) is extensively used as a solvent in surface coatings, such as lacquers, enamels, and varnishes in industrial and household cleaning products. Its major toxicity is manifested in the circulation, as it induces hemolytic anemia and thrombosis in various organs. While 2-BE has been implicated in the induction of anemia in different species, the rat has proven most sensitive, especially the female of this species. The purpose of this study was to document the effects of 2-BE on dentition, the periodontal ligament, the tongue, the salivary glands, and the oral mucosa in male and female Fischer 344 rats.
- Publication
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2004, Vol 33, Issue 7, p424
- ISSN
0904-2512
- Publication type
Journal Article
- DOI
10.1111/j.1600-0714.2004.00224.x