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- Title
Systemic vaccination prevents the total destruction of mucosal CD4 T cells during acute SIV challenge.
- Authors
Mattapallil, Joseph J; Hill, Brenna; Douek, Daniel C; Roederer, Mario
- Abstract
Acute human immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV) infections are accompanied by a systemic loss of memory CD4 T cells, with mucosal sites serving as a major site for viral replication, dissemination and CD4 T cell depletion. Protecting the mucosal CD4 T cell compartment thus is critical to contain HIV, and preserve the integrity of the mucosal immune system. The primary objective of this study was to determine if systemic vaccination with DNA/rAd-5 encoding SIV-mac239-env, gag and pol could prevent the destruction of CD4 T cells in mucosal tissues.
- Publication
Journal of medical primatology, 2006, Vol 35, Issue 4-5, p217
- ISSN
0047-2565
- Publication type
Journal Article
- DOI
10.1111/j.1600-0684.2006.00170.x