We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Inflammatory disease in HLA-B27 transgenic rats.
- Authors
Taurog, J D; Maika, S D; Satumtira, N; Dorris, M L; McLean, I L; Yanagisawa, H; Sayad, A; Stagg, A J; Fox, G M; Lê O'Brien, A; Rehman, M; Zhou, M; Weiner, A L; Splawski, J B; Richardson, J A; Hammer, R E
- Abstract
A spontaneous inflammatory disease in rats transgenic for HLA-B27 resembles the B27-associated human spondyloarthropathies. Colitis and arthritis, the two most important features, require T cells, gut bacteria, and high expression of B27 in bone marrow-derived cells. Control rats with HLA-B7 remain healthy. Most rats with HLA-Cw6 (associated with psoriasis vulgaris) remain healthy; a minority develop mild and transient disease. Rats with a mutant B27 with a Cys67-->Ser substitution resemble wild-type B27 transgenics, but with a lower prevalence of arthritis. A similar phenotype is seen in B27 rats co-expressing a viral peptide that binds B27. Disease-prone LEW but not F344 B27 rats develop high serum IgA levels concurrent with disease progression. Colitis is associated with high interferon-gamma, arthritis with high interleukin-6. Disease is similar in B27 LEW, F344, and PVG rats, but the DA background is protective.
- Publication
Immunological reviews, 1999, Vol 169, p209
- ISSN
0105-2896
- Publication type
Journal Article
- DOI
10.1111/j.1600-065x.1999.tb01317.x