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- Title
Structure, sequence and polymorphism in the HLA-D region.
- Authors
Trowsdale, J; Young, J A; Kelly, A P; Austin, P J; Carson, S; Meunier, H; So, A; Erlich, H A; Spielman, R S; Bodmer, J
- Abstract
Molecular analysis of the HLA-D region has uncovered a complex array of related genes encompassing a minimum of 6 alpha and 7 beta chain sequences. A high level of polymorphism is characteristic of the DQ alpha and beta genes, as well as DR beta. The DP genes, both alpha and beta, are also polymorphic, though to a lesser extent. The genes fit into the previously established loci: DP, DQ and DR, except for a newly-discovered sequence, DZ alpha, which is approximately equally related to all of the other alpha chain genes. Analysis of the polymorphism and evolution of the HLA-D region, by examination of the sequences, calls for several independent duplication events in the generation of this family of genes.
- Publication
Immunological reviews, 1985, Vol 85, p5
- ISSN
0105-2896
- Publication type
Journal Article
- DOI
10.1111/j.1600-065x.1985.tb01129.x