We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Molecular mechanisms of T-cell tolerance.
- Authors
Nurieva, Roza I; Liu, Xindong; Dong, Chen
- Abstract
CD4(+) T cells are the master regulators of adaptive immune responses, and many autoimmune diseases arise due to a breakdown of self-tolerance in CD4(+) T cells. Activation of CD4(+) T cells is regulated by not only the binding of peptide-major histocompatibility complexes to T-cell receptor but also costimulatory signals from antigen-presenting cells. Recently, there has been progress in understanding the extracellular and intracellular mechanisms that are required for implementation and maintenance of T-cell tolerance. Understanding of the molecular mechanisms underlying T-cell tolerance will lead to development of pharmacological approaches either to promote the tolerance state in terms of autoimmunity or to break tolerance in cancer.
- Publication
Immunological reviews, 2011, Vol 241, Issue 1, p133
- ISSN
1600-065X
- Publication type
Journal Article
- DOI
10.1111/j.1600-065X.2011.01012.x