We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Visualizing a role for the actin cytoskeleton in the regulation of B-cell activation.
- Authors
Batista, Facundo D; Treanor, Bebhinn; Harwood, Naomi E
- Abstract
Appropriate activation of B cells is required for mounting protective humoral immune responses. B-cell activation is initiated following specific recognition of antigen by the B-cell receptor (BCR) and results in the generation of antibody-secreting plasma cells and long-lived memory cells. Initial imaging approaches revealed that B cells undergo dramatic molecular and morphological reorganizations following recognition of antigen. A number of these studies pointed to a role for the underlying cytoskeleton in regulating early events of B-cell activation. More recently, groundbreaking advances in imaging technologies have enabled direct visualization of the role for the cytoskeleton in regulating events at the B-cell membrane. Indeed, we have demonstrated that an ezrin-defined actin network shapes BCR diffusion and signaling both in the resting state and following antigen-induced activation. Importantly, alongside these in vitro imaging approaches, it has been demonstrated that mutations in cytoskeleton regulators such as CD19, dedicator of cytokinesis 8 (DOCK8), and Wiskott-Aldrich syndrome protein (WASp) are often associated with antibody deficiency syndromes in humans, establishing the importance of cytoskeleton reorganizations in conferring effective adaptive immunity.
- Publication
Immunological reviews, 2010, Vol 237, Issue 1, p191
- ISSN
1600-065X
- Publication type
Journal Article
- DOI
10.1111/j.1600-065X.2010.00943.x