We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Increased expression of guanylate binding protein-1 in lesional skin of patients with cutaneous lupus erythematosus.
- Authors
Naschberger, Elisabeth; Wenzel, Jörg; Kretz, Cosima C; Herrmann, Martin; Stürzl, Michael; Kuhn, Annegret
- Abstract
The large GTPase human guanylate binding protein-1 (GBP-1) is a key mediator of angiostatic effects of inflammation and is induced by interferon (IFN)-α and IFN-γ in endothelial cells (ECs). The aim of this study was to investigate whether GBP-1 is a marker of skin lesions in patients with cutaneous lupus erythematosus (CLE). Western blotting revealed that GBP-1 was in vitro induced by IFN-α and -γ in primary keratinocytes obtained from healthy controls. Moreover, we found that this protein was expressed by keratinocytes and ECs in primary and ultraviolet (UV)-induced skin lesions from patients with various subtypes of CLE, when compared to non-lesional skin. No GBP-1 expression was noted in skin biopsy specimens 24 or 72 h after UV irradiation prior to lesion formation in patients with CLE or in healthy control specimens with or without UV irradiation. Initial findings suggest that GBP-1 is not expressed in other skin diseases with different inflammatory aetiology, such as atopic dermatitis. We conclude that GBP-1 expression is closely associated with skin lesions in patients with CLE, suggesting a contribution of GBP-1 in the pathogenesis of this disease.
- Publication
Experimental dermatology, 2011, Vol 20, Issue 2, p102
- ISSN
1600-0625
- Publication type
Journal Article
- DOI
10.1111/j.1600-0625.2010.01160.x