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- Title
Feasibility and efficacy of chronic transfusion for stroke prevention in children with sickle cell disease.
- Authors
Mirre, Elsa; Brousse, Valentine; Berteloot, Laureline; Lambot-Juhan, Karen; Verlhac, Suzanne; Boulat, Claire; Dumont, Marie-Dominique; Lenoir, Gérard; de Montalembert, Mariane
- Abstract
In children with sickle cell disease (SCD), chronic transfusion to maintain haemoglobin S (HbS) below 30% markedly decreases both the risk of a first stroke when transcranial Doppler (TCD) ultrasonography shows abnormal cerebral blood flow velocities and the risk of recurrent stroke. Maintaining HbS below 30% may be difficult, especially in countries where blood donors and recipients belong to different ethnic groups and where the availability of closely matched blood products is limited. We assessed the feasibility and efficacy of chronic transfusion with an HbS target of 30% in children with SCD living in the Paris area.
- Publication
European journal of haematology, 2010, Vol 84, Issue 3, p259
- ISSN
1600-0609
- Publication type
Journal Article
- DOI
10.1111/j.1600-0609.2009.01379.x